Distinct patterns of gene expression in human cardiac fibroblasts exposed to rapamycin treatment or methionine restriction.
Identifieur interne : 000618 ( Main/Exploration ); précédent : 000617; suivant : 000619Distinct patterns of gene expression in human cardiac fibroblasts exposed to rapamycin treatment or methionine restriction.
Auteurs : Ashley Azar [États-Unis] ; Ibiyonu Lawrence [États-Unis] ; Sebastian Jofre [États-Unis] ; Joshua Mell [États-Unis] ; Christian Sell [États-Unis]Source :
- Annals of the New York Academy of Sciences [ 1749-6632 ] ; 2018.
Descripteurs français
- KwdFr :
- Analyse en composantes principales (MeSH), Expression des gènes (MeSH), Fibroblastes (cytologie), Fibroblastes (effets des médicaments et des substances chimiques), Fibroblastes (métabolisme), Humains (MeSH), Marqueurs biologiques (métabolisme), Myocarde (cytologie), Myocarde (métabolisme), Méthionine (administration et posologie), Reproductibilité des résultats (MeSH), Sirolimus (pharmacologie), Vieillissement de la cellule (génétique).
- MESH :
- administration et posologie : Méthionine.
- cytologie : Fibroblastes, Myocarde.
- effets des médicaments et des substances chimiques : Fibroblastes.
- génétique : Vieillissement de la cellule.
- métabolisme : Fibroblastes, Marqueurs biologiques, Myocarde.
- pharmacologie : Sirolimus.
- Analyse en composantes principales, Expression des gènes, Humains, Reproductibilité des résultats.
English descriptors
- KwdEn :
- Biomarkers (metabolism), Cellular Senescence (genetics), Fibroblasts (cytology), Fibroblasts (drug effects), Fibroblasts (metabolism), Gene Expression (MeSH), Humans (MeSH), Methionine (administration & dosage), Myocardium (cytology), Myocardium (metabolism), Principal Component Analysis (MeSH), Reproducibility of Results (MeSH), Sirolimus (pharmacology).
- MESH :
- chemical , administration & dosage : Methionine.
- chemical , metabolism : Biomarkers.
- cytology : Fibroblasts, Myocardium.
- drug effects : Fibroblasts.
- genetics : Cellular Senescence.
- metabolism : Fibroblasts, Myocardium.
- chemical , pharmacology : Sirolimus.
- Gene Expression, Humans, Principal Component Analysis, Reproducibility of Results.
Abstract
Both methionine restriction and rapamycin treatment are robust longevity-enhancing regimens for which the mechanisms remain unclear. Cellular senescence is a major contributor to the aging process, and we find that both the methionine and rapamycin regimens delay or prevent activation of the senescence program in human cells. Using a transcriptome-wide analysis, we examined the impact of methionine restriction and rapamycin treatment on senescence-associated gene expression in human cardiac fibroblasts. Our findings have been integrated into gene expression data sets from human lung and skin fibroblasts during senescence. The data demonstrate both common and tissue-specific aspects to the senescent phenotype in these cell types. For example, cardiac fibroblasts express brain naturetic peptide, a clinically relevant marker for cardiac failure, whereas senescent cells from all three tissues express at least one of the insulin-like growth factor (IGF)-binding proteins. The IGF-binding proteins are tissue-specific mediators of IGF-1, a growth factor required for proliferation of all tissues. These data suggest that senescent cells serve tissue-specific roles. Moreover, the prolongevity regimens produce distinct patterns of gene expression.
DOI: 10.1111/nyas.13566
PubMed: 29377178
Affiliations:
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(cytology)</term><term>Myocardium (metabolism)</term><term>Principal Component Analysis (MeSH)</term><term>Reproducibility of Results (MeSH)</term><term>Sirolimus (pharmacology)</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Analyse en composantes principales (MeSH)</term><term>Expression des gènes (MeSH)</term><term>Fibroblastes (cytologie)</term><term>Fibroblastes (effets des médicaments et des substances chimiques)</term><term>Fibroblastes (métabolisme)</term><term>Humains (MeSH)</term><term>Marqueurs biologiques (métabolisme)</term><term>Myocarde (cytologie)</term><term>Myocarde (métabolisme)</term><term>Méthionine (administration et posologie)</term><term>Reproductibilité des résultats (MeSH)</term><term>Sirolimus (pharmacologie)</term><term>Vieillissement de la cellule (génétique)</term></keywords><keywords scheme="MESH" type="chemical" qualifier="administration & dosage" xml:lang="en"><term>Methionine</term></keywords><keywords scheme="MESH" type="chemical" 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Cellular senescence is a major contributor to the aging process, and we find that both the methionine and rapamycin regimens delay or prevent activation of the senescence program in human cells. Using a transcriptome-wide analysis, we examined the impact of methionine restriction and rapamycin treatment on senescence-associated gene expression in human cardiac fibroblasts. Our findings have been integrated into gene expression data sets from human lung and skin fibroblasts during senescence. The data demonstrate both common and tissue-specific aspects to the senescent phenotype in these cell types. For example, cardiac fibroblasts express brain naturetic peptide, a clinically relevant marker for cardiac failure, whereas senescent cells from all three tissues express at least one of the insulin-like growth factor (IGF)-binding proteins. The IGF-binding proteins are tissue-specific mediators of IGF-1, a growth factor required for proliferation of all tissues. These data suggest that senescent cells serve tissue-specific roles. Moreover, the prolongevity regimens produce distinct patterns of gene expression.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">29377178</PMID><DateCompleted><Year>2019</Year><Month>08</Month><Day>13</Day></DateCompleted><DateRevised><Year>2019</Year><Month>08</Month><Day>13</Day></DateRevised><Article PubModel="Print-Electronic"><Journal><ISSN IssnType="Electronic">1749-6632</ISSN><JournalIssue CitedMedium="Internet"><Volume>1418</Volume><Issue>1</Issue><PubDate><Year>2018</Year><Month>04</Month></PubDate></JournalIssue><Title>Annals of the New York Academy of Sciences</Title><ISOAbbreviation>Ann N Y Acad Sci</ISOAbbreviation></Journal><ArticleTitle>Distinct patterns of gene expression in human cardiac fibroblasts exposed to rapamycin treatment or methionine restriction.</ArticleTitle><Pagination><MedlinePgn>95-105</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1111/nyas.13566</ELocationID><Abstract><AbstractText>Both methionine restriction and rapamycin treatment are robust longevity-enhancing regimens for which the mechanisms remain unclear. Cellular senescence is a major contributor to the aging process, and we find that both the methionine and rapamycin regimens delay or prevent activation of the senescence program in human cells. Using a transcriptome-wide analysis, we examined the impact of methionine restriction and rapamycin treatment on senescence-associated gene expression in human cardiac fibroblasts. Our findings have been integrated into gene expression data sets from human lung and skin fibroblasts during senescence. The data demonstrate both common and tissue-specific aspects to the senescent phenotype in these cell types. For example, cardiac fibroblasts express brain naturetic peptide, a clinically relevant marker for cardiac failure, whereas senescent cells from all three tissues express at least one of the insulin-like growth factor (IGF)-binding proteins. The IGF-binding proteins are tissue-specific mediators of IGF-1, a growth factor required for proliferation of all tissues. These data suggest that senescent cells serve tissue-specific roles. Moreover, the prolongevity regimens produce distinct patterns of gene expression.</AbstractText><CopyrightInformation>© 2018 New York Academy of Sciences.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Azar</LastName><ForeName>Ashley</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>Department of Pathology, Drexel University College of Medicine, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lawrence</LastName><ForeName>Ibiyonu</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Department of Medicine, Drexel University College of Medicine, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Jofre</LastName><ForeName>Sebastian</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Pathology, Drexel University College of Medicine, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Mell</LastName><ForeName>Joshua</ForeName><Initials>J</Initials><AffiliationInfo><Affiliation>Department of Microbiology and Immunology, Drexel University College of Medicine, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Sell</LastName><ForeName>Christian</ForeName><Initials>C</Initials><AffiliationInfo><Affiliation>Department of Pathology, Drexel University College of Medicine, Philadelphia, Pennsylvania.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2018</Year><Month>01</Month><Day>28</Day></ArticleDate></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Ann N Y Acad 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MajorTopicYN="N">cytology</QualifierName><QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName><QualifierName UI="Q000378" MajorTopicYN="N">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015870" MajorTopicYN="Y">Gene Expression</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008715" MajorTopicYN="N">Methionine</DescriptorName><QualifierName UI="Q000008" MajorTopicYN="Y">administration & dosage</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D009206" MajorTopicYN="N">Myocardium</DescriptorName><QualifierName UI="Q000166" MajorTopicYN="N">cytology</QualifierName><QualifierName UI="Q000378" MajorTopicYN="Y">metabolism</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D025341" MajorTopicYN="N">Principal Component Analysis</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D015203" MajorTopicYN="N">Reproducibility of Results</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D020123" MajorTopicYN="N">Sirolimus</DescriptorName><QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="Y">aging</Keyword><Keyword MajorTopicYN="Y">cardiac</Keyword><Keyword MajorTopicYN="Y">methionine restriction</Keyword><Keyword MajorTopicYN="Y">rapamycin</Keyword><Keyword MajorTopicYN="Y">senescence</Keyword></KeywordList></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2017</Year><Month>07</Month><Day>28</Day></PubMedPubDate><PubMedPubDate PubStatus="revised"><Year>2017</Year><Month>10</Month><Day>27</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2017</Year><Month>10</Month><Day>31</Day></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2018</Year><Month>1</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2019</Year><Month>8</Month><Day>14</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2018</Year><Month>1</Month><Day>30</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">29377178</ArticleId><ArticleId IdType="doi">10.1111/nyas.13566</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>États-Unis</li></country><region><li>Pennsylvanie</li></region></list><tree><country name="États-Unis"><region name="Pennsylvanie"><name sortKey="Azar, Ashley" sort="Azar, Ashley" uniqKey="Azar A" first="Ashley" last="Azar">Ashley Azar</name></region><name sortKey="Jofre, Sebastian" sort="Jofre, Sebastian" uniqKey="Jofre S" first="Sebastian" last="Jofre">Sebastian Jofre</name><name sortKey="Lawrence, Ibiyonu" sort="Lawrence, Ibiyonu" uniqKey="Lawrence I" first="Ibiyonu" last="Lawrence">Ibiyonu Lawrence</name><name sortKey="Mell, Joshua" sort="Mell, Joshua" uniqKey="Mell J" first="Joshua" last="Mell">Joshua Mell</name><name sortKey="Sell, Christian" sort="Sell, Christian" uniqKey="Sell C" first="Christian" last="Sell">Christian Sell</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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